/* ============================================================
   Tokens
   ============================================================ */
:root{
  --paper: #eef1ef;
  --paper-raised: #f7f8f6;
  --ink: #12181b;
  --ink-soft: #454f52;
  --navy: #171d33;
  --navy-raised: #1f2744;
  --line: #d3d8d3;
  --line-dark: #333c5c;

  --hypoxia: #b7371f;   /* oxygen-deprived / failure zone */
  --hypoxia-soft: #e7c3ba;
  --oxygen: #1c7d69;    /* oxygen field */
  --drug: #3f5486;      /* drug concentration */
  --drug-soft: #ccd4e6;

  --font-display: "Fraunces", "Iowan Old Style", Georgia, serif;
  --font-body: "Inter", -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  --font-mono: "IBM Plex Mono", "SFMono-Regular", Menlo, Consolas, monospace;

  --max-w: 1120px;
}

*{box-sizing:border-box;}
html{scroll-behavior:smooth;}

body{
  margin:0;
  background:var(--paper);
  color:var(--ink);
  font-family:var(--font-body);
  font-size:16px;
  line-height:1.6;
  -webkit-font-smoothing:antialiased;
}

img{max-width:100%; display:block;}

a{color:var(--drug);}
a:hover{color:var(--hypoxia);}

.wrap{
  max-width:var(--max-w);
  margin:0 auto;
  padding:0 32px;
}

.eyebrow{
  font-family:var(--font-mono);
  font-size:12.5px;
  letter-spacing:0.09em;
  text-transform:uppercase;
  color:var(--hypoxia);
  margin:0 0 14px;
}

h1,h2,h3{
  font-family:var(--font-display);
  font-weight:600;
  letter-spacing:-0.01em;
  margin:0 0 0.5em;
}

h2{
  font-size:clamp(28px, 3.4vw, 40px);
  color:var(--ink);
}

h3{
  font-size:20px;
  font-weight:600;
}

p{margin:0 0 1em; max-width:70ch;}

.section{
  padding:88px 0;
  border-bottom:1px solid var(--line);
}

.section.on-navy{
  background:var(--navy);
  color:#eef1ef;
  border-bottom:1px solid var(--line-dark);
}
.section.on-navy h2, .section.on-navy h3{color:#f4f5f2;}
.section.on-navy p{color:#c3c8cf;}
.section.on-navy .eyebrow{color:#e28f7a;}

.lede{
  font-size:19px;
  color:var(--ink-soft);
  max-width:62ch;
}
.section.on-navy .lede{color:#c3c8cf;}

/* ============================================================
   Hero
   ============================================================ */
.hero{
  padding:72px 0 96px;
  background:
    radial-gradient(1100px 480px at 82% -10%, rgba(63,84,134,0.10), transparent 60%),
    var(--paper);
  border-bottom:1px solid var(--line);
}

.hero-grid{
  display:grid;
  grid-template-columns:1.15fr 0.85fr;
  gap:56px;
  align-items:center;
}

.hero-kicker{
  font-family:var(--font-mono);
  font-size:12.5px;
  letter-spacing:0.09em;
  text-transform:uppercase;
  color:var(--ink-soft);
  margin-bottom:20px;
  display:flex;
  gap:10px;
  align-items:center;
}
.hero-kicker .dot{
  width:6px; height:6px; border-radius:50%;
  background:var(--hypoxia);
  display:inline-block;
}

.hero h1{
  font-size:clamp(34px, 5vw, 54px);
  line-height:1.06;
  margin-bottom:22px;
}
.hero h1 em{
  font-style:italic;
  color:var(--hypoxia);
}

.hero-sub{
  font-size:18px;
  color:var(--ink-soft);
  max-width:56ch;
  margin-bottom:30px;
}

.hero-meta{
  font-family:var(--font-mono);
  font-size:13px;
  color:var(--ink-soft);
  display:flex;
  flex-wrap:wrap;
  gap:8px 22px;
  margin-bottom:34px;
}
.hero-meta strong{color:var(--ink); font-weight:600;}

.btn-row{display:flex; gap:12px; flex-wrap:wrap;}

.btn{
  font-family:var(--font-mono);
  font-size:13px;
  letter-spacing:0.02em;
  padding:12px 20px;
  border-radius:3px;
  text-decoration:none;
  display:inline-flex;
  align-items:center;
  gap:8px;
  border:1px solid var(--ink);
  transition:transform 0.15s ease, background 0.15s ease, color 0.15s ease;
}
.btn-primary{background:var(--ink); color:var(--paper);}
.btn-primary:hover{background:var(--hypoxia); border-color:var(--hypoxia); color:#fff; transform:translateY(-1px);}
.btn-ghost{background:transparent; color:var(--ink); border-color:var(--line-dark);}
.btn-ghost:hover{border-color:var(--ink); color:var(--ink); transform:translateY(-1px);}

/* ---- signature diagram ---- */
.rings-frame{
  position:relative;
  aspect-ratio:1/1;
  display:flex;
  align-items:center;
  justify-content:center;
}
.rings-caption{
  font-family:var(--font-mono);
  font-size:11.5px;
  color:var(--ink-soft);
  text-align:center;
  margin-top:14px;
  line-height:1.5;
}
.rings-caption b{color:var(--ink); font-weight:600;}

@media (prefers-reduced-motion: no-preference){
  .pulse-ring{ animation: pulseRing 6.3s ease-in-out infinite; transform-origin:center; }
  .pulse-ring.r2{ animation-delay:0.4s; }
  .pulse-ring.r3{ animation-delay:0.8s; }
  .pulse-core{ animation: pulseCore 6.3s ease-in-out infinite; transform-origin:center; }
}
@keyframes pulseRing{
  0%, 100%{ opacity:0.25; }
  8%{ opacity:0.95; }
  40%{ opacity:0.15; }
}
@keyframes pulseCore{
  0%, 100%{ opacity:0.7; }
  8%{ opacity:1; }
  40%{ opacity:0.55; }
}

/* ============================================================
   Stat strip
   ============================================================ */
.stat-strip{
  display:grid;
  grid-template-columns:repeat(4, 1fr);
  border-top:1px solid var(--line);
  border-bottom:1px solid var(--line);
  background:var(--paper-raised);
}
.stat{
  padding:30px 28px;
  border-right:1px solid var(--line);
}
.stat:last-child{border-right:none;}
.stat .num{
  font-family:var(--font-display);
  font-size:34px;
  font-weight:600;
  color:var(--hypoxia);
  line-height:1;
  margin-bottom:8px;
}
.stat .label{
  font-family:var(--font-mono);
  font-size:12.5px;
  color:var(--ink-soft);
  line-height:1.45;
}

@media (max-width:800px){
  .stat-strip{grid-template-columns:repeat(2,1fr);}
  .stat:nth-child(2){border-right:none;}
}

/* ============================================================
   Two column content blocks
   ============================================================ */
.split{
  display:grid;
  grid-template-columns:0.9fr 1.1fr;
  gap:56px;
  align-items:start;
}
.split.rev{grid-template-columns:1.1fr 0.9fr;}
.split.rev .split-media{order:2;}

.split-media img{
  border:1px solid var(--line);
  background:#fff;
}
.on-navy .split-media img{border-color:var(--line-dark);}

.figcap{
  font-family:var(--font-mono);
  font-size:12.5px;
  color:var(--ink-soft);
  margin-top:10px;
  line-height:1.55;
}
.on-navy .figcap{color:#9aa1ac;}

@media (max-width:860px){
  .split, .split.rev{grid-template-columns:1fr;}
  .split.rev .split-media{order:0;}
}

/* ============================================================
   Theorem cards
   ============================================================ */
.theorem-list{
  display:grid;
  gap:1px;
  background:var(--line-dark);
  border:1px solid var(--line-dark);
  margin-top:44px;
}
.theorem{
  background:var(--navy);
  padding:34px 36px;
  display:grid;
  grid-template-columns:64px 1fr;
  gap:24px;
}
.theorem .tnum{
  font-family:var(--font-display);
  font-size:40px;
  font-weight:600;
  color:var(--hypoxia-soft);
  line-height:1;
}
.theorem h3{margin-bottom:10px; color:#f4f5f2;}
.theorem p{color:#c3c8cf; margin-bottom:0.7em;}
.theorem .formula{
  font-family:var(--font-mono);
  font-size:13.5px;
  color:#e6cdc4;
  background:rgba(183,55,31,0.12);
  border-left:2px solid var(--hypoxia);
  padding:10px 14px;
  margin:14px 0;
  overflow-x:auto;
}
.theorem .verdict{
  font-family:var(--font-mono);
  font-size:12.5px;
  color:#9fd7c4;
  margin-top:10px;
}

@media (max-width:640px){
  .theorem{grid-template-columns:1fr; gap:8px;}
}

/* ============================================================
   Pipeline steps
   ============================================================ */
.pipeline{
  display:grid;
  grid-template-columns:repeat(4,1fr);
  gap:24px;
  margin-top:20px;
}
.pipe-step{
  border-top:2px solid var(--ink);
  padding-top:14px;
}
.pipe-step .pnum{
  font-family:var(--font-mono);
  font-size:12px;
  color:var(--hypoxia);
}
.pipe-step h3{font-size:16.5px; margin:6px 0 8px;}
.pipe-step p{font-size:14.5px; color:var(--ink-soft); margin-bottom:0;}

@media (max-width:860px){
  .pipeline{grid-template-columns:1fr 1fr;}
}
@media (max-width:520px){
  .pipeline{grid-template-columns:1fr;}
}

/* ============================================================
   Tables
   ============================================================ */
.table-wrap{
  overflow-x:auto;
  margin-top:28px;
  border:1px solid var(--line);
}
table{
  border-collapse:collapse;
  width:100%;
  font-family:var(--font-mono);
  font-size:13.2px;
  background:var(--paper-raised);
}
th, td{
  padding:10px 14px;
  text-align:left;
  border-bottom:1px solid var(--line);
  white-space:nowrap;
}
th{
  font-weight:600;
  color:var(--ink);
  background:#e4e8e3;
  letter-spacing:0.01em;
}
td{color:var(--ink-soft);}
tr:hover td{background:#f1f3ef; color:var(--ink);}
.pcr-1{color:var(--oxygen); font-weight:600;}
.pcr-0{color:var(--hypoxia); font-weight:600;}

/* ============================================================
   Result grid (ablation)
   ============================================================ */
.ablation-grid{
  display:grid;
  grid-template-columns:repeat(3, 1fr);
  gap:1px;
  background:var(--line);
  border:1px solid var(--line);
  margin-top:28px;
}
.ablation-cell{
  background:var(--paper-raised);
  color:var(--ink);
  padding:24px 22px;
}
.ablation-cell h4{
  font-family:var(--font-mono);
  font-size:12.5px;
  text-transform:uppercase;
  letter-spacing:0.06em;
  color:var(--ink-soft);
  margin:0 0 14px;
}
.ablation-cell .auc{
  font-family:var(--font-display);
  font-size:15px;
  margin:4px 0;
  color:var(--ink-soft);
}
.ablation-cell .auc b{
  font-size:22px;
  margin-right:6px;
  color:var(--ink);
}

@media (max-width:760px){
  .ablation-grid{grid-template-columns:1fr;}
}

/* ============================================================
   Limitations / clinical list
   ============================================================ */
.checklist{
  list-style:none;
  padding:0;
  margin:28px 0 0;
  display:grid;
  gap:1px;
  background:var(--line);
  border:1px solid var(--line);
}
.checklist li{
  background:var(--paper-raised);
  padding:20px 24px;
  display:grid;
  grid-template-columns:28px 1fr;
  gap:14px;
}
.checklist .mark{
  font-family:var(--font-mono);
  color:var(--hypoxia);
  font-weight:600;
}
.checklist p{margin:0; font-size:14.5px;}
.checklist strong{color:var(--ink);}

/* ============================================================
   Footer / citation
   ============================================================ */
.footer{
  background:var(--navy);
  color:#c3c8cf;
  padding:64px 0 40px;
}
.footer h3{color:#f4f5f2;}
.cite-block{
  font-family:var(--font-mono);
  font-size:13px;
  line-height:1.7;
  background:rgba(255,255,255,0.04);
  border:1px solid var(--line-dark);
  padding:22px 24px;
  margin:22px 0 30px;
  color:#dfe2e0;
  overflow-x:auto;
}
.footer-links{
  display:flex;
  gap:28px;
  flex-wrap:wrap;
  font-family:var(--font-mono);
  font-size:13px;
  margin-bottom:36px;
}
.footer-links a{color:#dfe2e0;}
.footer-links a:hover{color:var(--hypoxia-soft);}
.footer-bottom{
  border-top:1px solid var(--line-dark);
  padding-top:24px;
  font-size:12.5px;
  color:#7d8590;
  display:flex;
  justify-content:space-between;
  flex-wrap:wrap;
  gap:10px;
}

/* ============================================================
   Misc
   ============================================================ */
.small-note{
  font-family:var(--font-mono);
  font-size:12.5px;
  color:var(--ink-soft);
  border-left:2px solid var(--drug);
  padding-left:14px;
  margin-top:26px;
}
.on-navy .small-note{border-left-color:var(--hypoxia-soft);}

.two-col-text{
  display:grid;
  grid-template-columns:1fr 1fr;
  gap:48px;
}
@media (max-width:760px){
  .two-col-text{grid-template-columns:1fr;}
}

::selection{background:var(--hypoxia); color:#fff;}